About TB - TB FAQ

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Introduction

What is TB?

TB, or tuberculosis, is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria can attack any part of your body, but they usually attack the lungs. TB disease was once the leading cause of death in the United States.

In the 1940s, scientists discovered the first of several drugs now used to treat TB. As a result, TB slowly began to disappear in the United States. But TB has come back. After 1984, the number of TB cases reported in the United States began to increase. More than 25,000 cases were reported in 1992.

TB is spread through the air from one person to another. The bacteria are put into the air when a person with TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected.

People who are infected with TB do not feel sick, do not have any symptoms, and cannot spread TB. But they may develop TB disease at some time in the future. People with TB disease can be treated and cured if they seek medical help. Even better, people who have TB infection but are not yet sick can take medicine so that they will never develop TB disease.

How is TB spread?

TB is spread through the air from one person to another. The bacteria are put into the air when a person with TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected.

When a person breathes in TB bacteria, the bacteria can settle in the lungs and begin to grow. From there, they move through the blood to other parts of the body, such as the kidney, spine, and brain.

TB in the lungs or throat can be infectious. This means that the bacteria can be spread to other people. TB in other parts of the body, such as the kidney or spine, is usually not infectious.

People with TB disease are most likely to spread it to people they spend time with every day. This includes family members, friends, and coworkers.

What is TB infection?

In most people who breathe in TB bacteria and become infected, the body is able to fight the bacteria to stop them from growing. The bacteria become inactive, but they remain alive in the body and can become active later. This is called TB infection. People with TB infection:

  • Have no symptoms
  • Don't feel sick
  • Can't spread TB to others
  • Usually have a positive skin test reaction and a positive interferon gamma release assay (IGRA) result
  • Can develop TB disease later in life if they do not receive treatment for their TB infection

Many people who have TB infection never develop TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease. But in other people, especially people who have weak immune systems, the bacteria become active and cause TB disease.

What is TB disease?

TB bacteria become active if the immune system can't stop them from growing. The active bacteria begin to multiply in the body and cause TB disease. Some people develop TB disease soon after becoming infected, before their immune system can fight the TB bacteria. Other people may get sick later, when their immune system becomes weak for some reason.

Babies and young children often have weak immune systems. People infected with HIV, the virus that causes AIDS, have very weak immune systems. Other people can have weak immune systems, too, especially people with any of these conditions:

  • Substance abuse
  • Diabetes mellitus
  • Silicosis
  • Cancer of the head or neck
  • Leukemia or Hodgkin's disease
  • Severe kidney disease
  • Low body weight
  • Certain medical treatments (such as corticosteroid treatment or organ transplants)

Symptoms of TB depend on where in the body the TB bacteria are growing. TB bacteria usually grow in the lungs. TB in the lungs may cause:

  • A bad cough that lasts longer than 2 weeks
  • Pain in the chest
  • Coughing up blood or sputum (phlegm from deep inside the lungs)

Other symptoms of TB disease maybe:

  • Weakness or fatigue
  • Weight loss
  • No appetite
  • Chills
  • Fever
  • Sweating at night

TB Infection

How can I get tested for TB?

A TB skin test or a blood test with QuantiFERON TB Gold ® is the only way to find out if you have TB infection. You can get a skin test at the health department or at your doctor's office. You should get tested for TB if:

  • You have spent time with a person with infectious TB
  • You have HIV infection or another condition that puts you at high risk for TB disease
  • You think you might have TB disease
  • You are from a country where TB disease is very common (most countries in Latin America and the Caribbean , Africa , and Asia , except for Japan )
  • You inject drugs
  • You live somewhere in the U.S. where TB disease is common (most homeless shelters, migrant farm camps, prisons and jails, and some nursing homes)

A health care worker can give you the TB skin test. He or she will inject a small amount of testing fluid (called tuberculin) just under the skin on the lower part of your arm. After 2 or 3 days, the health care worker will measure your reaction to the test. You may have a small bump where the tuberculin was injected. The health care worker will tell you if your reaction to the test is positive or negative. A positive reaction usually means that you have TB infection.

If you have a positive reaction to the skin test, your doctor or nurse may do other tests to see if you have TB disease. These tests usually include a chest x-ray and a test of the phlegm you cough up. Because the TB bacteria may be found somewhere besides your lungs, your doctor or nurse may check your blood or urine, or do other tests. If you have TB disease, you will need to take medicine to cure the disease.

If you have recently spent time with someone with infectious TB, your skin test reaction may not be positive yet. You may need a second skin test 10 to 12 weeks after the last time you spent time with the infectious person. This is because it can take several weeks after infection for your immune system to be able to react to the TB skin test. If your reaction to the second test is negative, you probably do not have TB infection.

What if I have been vaccinated with BCG?

BCG is a vaccine for TB. This vaccine has never been widely used in the United States, but it is often given to infants and small children in other countries where TB is common. BCG vaccine does not usually protect people from TB.

If you were vaccinated with BCG, you may have a positive reaction to a TB skin test. This reaction may be due to the BCG vaccine itself or to a real TB infection. But your positive reaction probably means that you have TB infection if:

  • Your skin test reaction is large
  • You were vaccinated many years ago (because the BCG reaction gets smaller over time)
  • You have ever spent time with a person with infectious TB
  • Someone in your family has had TB
  • You are from a country where TB disease is very common (most countries in Latin America and the Caribbean , Africa , and Asia , except for Japan )

QuantiFERON TB Gold ® is specific for TB Infection and is not positive in people who have been vaccinated with BCG.

If I have TB infection, how can I keep from developing TB disease?

Many people who have TB infection never develop TB disease. But some people who have TB infection are more likely to develop TB disease than others. These people are at high risk for TB disease. They include:

  • People with HIV infection
  • People in close contact with a person who has infectious TB
  • People who became infected with TB bacteria in the last 2 years
  • Babies and young children
  • People who inject drugs
  • People who are sick with other diseases that weaken the immune system
  • Elderly people

If you have TB infection (a positive skin test reaction) and you are in one of these high-risk groups, you need to take medicine to keep from developing TB disease. This kind of treatment is called Treatment for Latent TB Infection.

People who have TB infection but do not receive this treatment need to know the symptoms of TB. If they develop symptoms of TB disease later on, they should see a doctor right away.

The medicine usually used for treatment latent TB infection is a drug called isoniazid or INH. INH kills the TB bacteria that are inactive in the body. If you take your medicine as prescribed, treatment of latent TB infection will keep you from developing TB disease.

Most people must take INH for at least 9 months. An effective alternative regimen that maybe considered is rifampin for 4 months daily.

Sometimes people are given treatment for latent infection even if their skin test reaction is not positive. This is often done with infants, children, and HIV-infected people who have recently spent time with someone with infectious TB disease. This is because they are at very high risk of developing serious TB disease soon after they become infected with TB bacteria and the skin test might be inaccurate in these people.

It is important that you take all the pills prescribed for you so that your treatment therapy is effective. If you start taking INH, you will need to see your doctor or nurse on a regular schedule. He or she will check on how you are doing. Very few people have serious side effects to INH. However, if you have any of the following side effects call your doctor or nurse right away:

  • No appetite
  • Nausea
  • Vomiting
  • Yellowish skin or eyes
  • Fever for more 3 days
  • Abdominal pain
  • Tingling in the fingers and toes

Warning: Drinking excessive alcoholic beverages (wine, beer, and liquor) while taking INH can be dangerous. Check with your doctor or nurse for more information.

What if I have HIV infection?

A person can have TB infection for years without any signs of disease. But if that person's immune system gets weak, the infection can quickly turn into TB disease. Also, if a person who has a weak immune system spends time with someone with infectious TB, he or she may become infected with TB bacteria and quickly develop TB disease.

Because HIV infection weakens the immune system, people with TB infection and HIV infection are at very high risk of developing TB disease. All HIV-infected people should be given a TB skin test to find out if they have TB infection. If they have TB infection, they need treatment of latent TB infection as soon as possible to prevent them from developing TB disease. If they have TB disease, they must take medicine to cure the disease.

TB disease can be prevented or cured in people with HIV infection.



TB Disease

How is TB disease treated?

There is good news for people with TB disease! TB disease can almost always be cured with medicine. But the medicine must be taken as the doctor or nurse tells you.

The most common drugs used to fight TB are:

  • Isoniazid (INH)
  • Rifampin ( RIF)
  • Pyrazinamide (PZA)
  • Ethambutol (EMB)

If you have TB disease, you will need to take several different drugs. This is because there are many bacteria to be killed. Taking several drugs will do a better job of killing all of the bacteria and preventing them from becoming resistant to the drugs.

If you have TB of the lungs or throat, you are probably infectious. You need to stay home from work or school so that you don't spread TB bacteria to other people. After taking your medicine for a few weeks, you will feel better and you may no longer be infectious to others. Your doctor or nurse will tell you when you can return to work or school.

Having TB should not stop you from leading a normal life. When you are no longer infectious or feeling sick, you can do the same things you did before you had TB. The medicine that you are taking should not affect your strength, sexual function, or ability to work. If you take your medicine as your doctor or nurse tells you, the medicine will kill all the TB bacteria. This will keep you from becoming sick again.

What are the side effects of drugs for TB?

Medicine for TB is relatively safe. Occasionally like any drug, these drugs may cause side effects. Some side effects are minor problems. Others are more serious. If you have a serious side effect, call your doctor or nurse immediately. You may be told to stop taking your medicine or to return to the clinic for tests.

The side effects listed below are serious. If you have any of these symptoms, call your doctor or nurse immediately:

  • No appetite
  • Nausea
  • Vomiting
  • Yellowish skin or eyes
  • Fever for 3 or more days
  • Abdominal pain
  • Tingling fingers or toes
  • Skin rash
  • Easy bleeding
  • Aching joints
  • Dizziness
  • Tingling or numbness around the mouth
  • Easy bruising
  • Blurred or changed vision
  • Ringing in the ears

The side effects listed below are less serious problems. If you have any of these side effects, you can continue taking your medicine:

  • Rifampin can turn urine, saliva, or tears orange. The doctor or nurse may advise you not to wear soft contact lenses because they may get stained.
  • Rifampin can make you more sensitive to the sun. This means you should use a good sunscreen and cover exposed areas so you don't burn.
  • Rifampin also makes birth control pills and implants less effective. Women who take rifampin should use another form of birth control.
  • If you are taking rifampin as well as methadone (used to treat drug addiction), you may have withdrawal symptoms. Your doctor or nurse may want to adjust your methadone dosage.

Why do I need to take TB medicine regularly?

TB bacteria die very slowly. It takes at least 6 months for the medicine to kill all the TB bacteria. You will probably start feeling well after only a few weeks of treatment. But beware! The TB bacteria are still alive in your body. You must continue to take your medicine until all the TB bacteria are dead, even though you may feel better and have no more symptoms of TB disease.

If you don't continue taking your medicine after you feel better or you aren't taking your medicine regularly, this can be very dangerous. The TB bacteria will grow again and you will relapse or remain sick for a longer time. The bacteria may also become resistant to the drugs you are taking. You may need new, different drugs to kill the TB bacteria if the old drugs no longer work. These new drugs must be taken for a longer time and usually have more serious side effects.

If you become infectious again, you could give TB bacteria to your family, friends, or anyone else who spends time with you. It is very important to take your medicine the way your doctor or nurse tells you.

How can I remember to take my medicine?

The only way to get well is to take your medicine exactly as your doctor or nurse tells you. This will not be easy! You will be taking your medicine for a long time (6 months or longer), so you should get into a routine. Here are some ways to remember to take your medicine:

  • Participate in the directly observed therapy (DOT) program at your health department.
  • Take your pills at the same time every day -- for example, you can take them before eating breakfast, during a coffee break, or after brushing your teeth.
  • Ask a family member or a friend to remind you to take your pills.
  • Mark off each day on a calendar as your take your medicine.
  • Put your pills in a weekly pill dispenser. Keep it by your bed or in your purse or pocket.

NOTE: Remember to keep all medicine out of reach of children.

If you forget to take your pills one day, skip that dose and take the next scheduled dose. Tell your doctor or nurse that you missed a dose. You may also call your doctor or nurse for instructions.

The best way to remember to take your medicine is to get directly observed therapy (DOT). If you get DOT, you will meet with a health care worker every day or several times a week. Usually you will meet at a place you both agree on. This might be the TB clinic, your home or work, or any other convenient location. You will take your medicine at this place.

DOT helps in several ways. The health care worker can help you remember to take your medicine and complete your treatment. This means you will get well as soon as possible. With DOT, you may need to take medicine only 2 or 3 times each week instead of every day. The health care worker will make sure that the medicine is working as it should. This person will also watch for side effects and answer questions you have about TB.

Even if you are not getting DOT, you must be checked at different times to make sure everything is going well. You should see your doctor or nurse regularly while you are taking your medicine. This will continue until you are cured.

How can I keep from spreading TB?

The most important way to keep from spreading TB is to take all your medicine, exactly as told by your doctor or nurse. You should also keep all of your doctor's appointments! Your doctor or nurse needs to see how you are doing. You may need another chest x-ray or a test of the phlegm you may cough up. These tests will show whether the medicine is working. They will also show whether you can still give TB bacteria to others. Be sure to tell the doctor about anything you think is wrong.

If you are sick enough with TB to go to a hospital, you may be put in a special room. These rooms use air vents that keep TB bacteria from spreading. People who work in these rooms must wear a special face mask to protect themselves from TB bacteria. You must stay in the room so that you will not spread TB bacteria to other people. Ask a nurse if you need anything that is not in your room.

If you are infectious while you are at home, there are certain things you can do to protect yourself and others near you. Your doctor may tell you to follow these guidelines to protect yourself and others:

  • The most important thing is to take your medicine.
  • Always cover your mouth with a tissue when you cough, sneeze, or laugh. Put the tissue in a closed bag and throw it away.
  • Do not go to work or school. Separate yourself from others and avoid close contact with anyone. Sleep in a bedroom away from other family members.
  • Air out your room often (if it is not too cold outside). TB spreads in small closed spaces where air doesn't move. Put a fan in your window to blow out (exhaust) air that may be filled with TB bacteria. If you open other windows in the room, the fan also will pull in fresh air. This will reduce the chances that TB bacteria stay in the room and infect someone who breathes the air.

Remember, TB is spread through the air. People cannot get infected with TB bacteria through handshakes, sitting on toilet seats, or sharing dishes and utensils with someone who has TB.

After you take medicine for about 2 or 3 weeks, you may no longer be able to spread TB bacteria to others. If your doctor or nurse agrees, you will be able to go back to your daily routine. Remember, you will get well only if your take your medicine exactly as your doctor or nurse tells you.

Think about people who may have spent time with you in the immediate period prior to your diagnosis, such as family members, close friends, and coworkers. The local health department may need to test them for TB infection. TB is especially dangerous for children and people with HIV infection. If infected with TB bacteria, these people need treatment for latent TB infection right away to keep from developing TB disease.

What is multidrug-resistant TB?

When TB patients do not take their medicine as prescribed, the TB bacteria may become resistant to a certain drug. This means that the drug can no longer kill the bacteria.

Drug resistance is more common in people who:

  • Have spent time with someone with drug-resistant TB disease
  • Do not take their medicine regularly
  • Do not take all of their prescribed medicine
  • Develop TB disease again, after having taken TB medicine in the past
  • Come from areas where drug-resistant TB is more common (former Soviet Union , Southeast Asia , Latin America , Haiti , and the Philippines )

Sometimes the bacteria become resistant to more than one drug. This is called multidrug-resistant TB, or MDR TB. This is a very serious problem. People with MDR TB disease must be treated with special drugs. These drugs are not as good as the usual drugs for TB and they may cause more side effects. Also, some people with MDR TB disease must see a TB expert who can closely observe their treatment to make sure it is working.

People who have spent time with someone sick with MDR TB disease can become infected with TB bacteria that are resistant to several drugs. If they have a positive skin test reaction, they may be given treatment for latent TB infection depends on the drug susceptibility profile of the person sick with TB. This is very important for people who are at high risk of developing MDR TB disease, such as children and HIV-infected people.