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This may be in response to a trigger, such as weakening of the immune system by HIV infection.
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The immune response of the patient results in a pathological lesion that is characteristically localized, often with lung tissue destruction and cavitation.
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Among adults, TB disease usually affects the lungs, but can involve any part of the body.
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The characteristic features of post-primary PTB are extensive lung destruction with cavitation and positive sputum smears and/or culture. Therefore, this form of TB is often far more infectious than primary TB.
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