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- Rifampicin is the only rifamycin available in most of the world, and initial antiretroviral regimens in areas with high rates of TB consist of EFV or NVP (in combination with nucleoside analogues).
- Because of its potency and durability in randomized clinical trials, EFV-based therapy is a preferred option for initial ART (Ref.)
- There are a certain considerations based on drug-drug interactions between rifampicin and NNRTIs, EFV and NVP.
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