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Rifampicin and Efavirenz
- EFV-based ART and rifampicin-based TB treatment, at their standard doses—is the preferred treatment for HIV-related TB.
- Rifampicin causes a measurable, though modest, decrease in EFV concentrations.
- However trough concentrations of EFV, the best predictor of its virological activity, remain well above the concentration necessary to suppress HIV in-vitro among patients on concomitant rifampicin.
- Some experts recommend an 800 mg dose of EFV rather than the standard 600 mg dose for patients weighing >60 kg.(Ref) Since recommended HIV treatment regimens can change, consulting with an HIV expert should be considered.
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