New patients should receive a regimen containing 6 months of rifampicin.
Ethambutol should not be excluded during the intensive phase of treatment for patients with non-cavitary, smear-negative pulmonary TB or extrapulmonary disease who are known to be HIV-negative.
In populations with known or suspected high levels of isoniazid resistance new TB patients may receive HRE as therapy in the continuation phase as an acceptable alternative to HR.