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Serologic and other diagnostic tests for active TB

  • A number of serologic tests are based on detection of antibodies to a variety of mycobacterial antigens.

  • Careful independent assessments suggest that they are not useful as diagnostic aids, especially in persons with low probability of TB and WHO has recommended against their use.

  • Various methods aimed at detection of mycobacterial antigens in diagnostic specimens are being investigated but are limited at present by low sensitivity.
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